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Your doctor will diagnose peripheral artery disease based on your medical and family histories, a physical exam, and results from one or more tests: ankle-brachial index, Doppler ultrasound, treadmill test, magnetic resonance angiogram (MRA), arteriogram, and blood tests.

Peripheral artery disease is more common in blacks than any other racial or ethnic group. The major risk factors for peripheral artery disease include smoking, older age, and diseases and conditions such as diabetes, high blood pressure, high blood cholesterol, coronary heart disease, stroke, and metabolic syndrome.

Atherosclerosis is the main cause of PAD. Plaque buildup in the arteries is called atherosclerosis. Atherosclerosis is a disease in which a waxy substance called plaque builds up on the inner lining of arteries. Plaque is made up of fat, cholesterol, fibrous tissue, and calcium. In PAD, plaque may reduce or fully block the flow of oxygen-rich blood through arteries to the body’s vital organs and the limbs.

Peripheral artery disease happens when plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque buildup leads to atherosclerosis, which limits oxygen-rich blood flow to your organs and other parts of your body. This Health Topic focuses on peripheral artery disease that affects blood flow to the legs.

People living with mitral valve prolapse should receive ongoing care, take all medicines as prescribed, and make heart-healthy lifestyle choices.

Doctors usually detect mitral valve prolapse when they hear a heart murmur or abnormal heart sounds during a physical exam. To diagnose this condition your doctor may order the following tests and procedures: echocardiography with Doppler ultrasound, chest x ray, and electrocardiogram (EKG).

Mitral valve prolapse is a condition in which the flaps of the mitral valve are floppy, or prolapsed, which can prevent the seal from forming, which results in a backflow of blood in the left atrium as blood is pumped through the heart.

Your doctor will diagnose metabolic syndrome based on the results of a physical exam and blood tests. You must have at least three of the five metabolic risk factors—a large waistline, a high triglyceride level, a low HDL cholesterol level, high blood pressure, and high fasting blood sugar—to be diagnosed with metabolic syndrome.

Most of the metabolic risk factors have no signs or symptoms, although a large waistline is a visible sign. Some people may have symptoms of high blood sugar if diabetes is present.

People at greatest risk for metabolic syndrome have high abdominal obesity, an inactive lifestyle, and insulin resistance. Some racial and ethnic groups in the United States are at higher risk for metabolic syndrome than others.

Metabolic syndrome has several causes that act together. You can control some of the causes, such as overweight and obesity, an inactive lifestyle, and insulin resistance. You can’t control other factors, such as growing older, genetics, or coexisting conditions such as excessive blood clotting and constant, low-grade inflammation.

Metabolic syndrome is the name for a group of risk factors that raises your risk for heart disease and other health problems, such as diabetes and stroke. The term "metabolic" refers to the biochemical processes involved in the body's normal functioning.

Heart valve disease occurs if one or more of your heart valves don't work well. The heart has four valves—the tricuspid, pulmonary, mitral, and aortic valves—that make sure blood flows in the right direction through your heart’s four chambers and to the rest of your body.

If you are living with heart failure, you should follow your lifelong treatment plan, take steps to prevent heart failure from getting worse, plan ahead, and obtain emotional support.

You can take action to prevent heart disease and heart failure by avoiding illegal drugs, being physically active, following a heart-healthy eating plan, quitting smoking, and maintaining a healthy weight.