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ALS stands for amyotrophic lateral sclerosis. It’s also called Lou Gehrig’s disease. ALS attacks motor neurons, the nerve cells responsible for regulating “voluntary” muscles that we’re aware of controlling, such as those in our arms, legs, and face. As these motor neurons degenerate or die, they stop sending signals to muscles. Unable to function, the muscles gradually weaken and waste away.

Do you tend to look on the sunny side, or do you see a future filled with dark, stormy skies? A growing body of research suggests that having a positive outlook can benefit your physical health. NIH-funded scientists are working to better understand the links between your attitude and your body. They’re finding some evidence that emotional wellness can be improved by developing certain skills.

For those who dream of being parents, pregnancy problems can be tremendously frustrating and disappointing. In recent decades, scientists have developed a wide range of approaches to help struggling couples have healthy babies. And NIH-funded studies are continuing to search for even better ways to overcome the challenges of infertility.

As you age, you may notice you have less muscle and energy and more fat. Carrying those extra pounds may be harming your health. It’s easy to be confused by advice about diet and exercise, but they’re key to avoiding weight gain as you get older.

The majority of competing applications now require electronic application submission. The Funding Opportunity Announcement (FOA) to which you are applying will identify whether you must submit electronically or use paper submission. Note that paper submissions require use of the PHS 398 application form, while electronic submission requires the SF424 (R&R) application.

Around the Nation and Worldwide NIH conducts clinical research trials for many diseases and conditions, including cancer, Alzheimer’s disease, allergy and infectious diseases, and neurological disorders. To search for other diseases and conditions, you can visit ClinicalTrials.gov.