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NIH - Office of Research on Women's Health

Methods & Techniques for Integrating Sex into Research

One of the fundamental variables in preclinical biomedical research is sex: whether a cell, tissue, or animal is female or male. Biological sex is an important consideration for this research that underlies drug development, clinical trials, and prevention approaches.

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NIH - Office of Research on Women's Health

NIH Policy on Sex as a Biological Variable

NIH expects that sex as a biological variable will be factored into research designs, analyses, and reporting in vertebrate animal and human studies. Strong justification from the scientific literature, preliminary data, or other relevant considerations must be provided for applications proposing to study only one sex.

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