The NIH announces new review criteria for research project applications involving clinical trials (September 21-2017) Additional review questions will be effective for all clinical trial applications for research project grants and cooperative agreements that are submitted for funding consideration for due dates on or after January 25, 2018. For the evaluation of those applications, new questions will be added to the existing review questions, which will not change for research project applications that do not involve clinical trials. Some Program Announcements and Requests for Applications may include FOA-specific questions in addition to those below.