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NHLBI

Trastornos hemorrágicos - Signos, síntomas y complicaciones

Los signos, síntomas y complicaciones pueden variar según el tipo de trastorno hemorrágico, su causa y si el trastorno es leve o más grave. Los signos y síntomas pueden ser obvios poco después del nacimiento de un niño o pueden no aparecer hasta la edad adulta. Las personas que tienen un trastorno hemorrágico leve pueden no tener ningún signo o síntoma hasta que se lesionen o tengan un procedimiento médico.

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NHLBI

Trastornos hemorrágicos - Factores de riesgo

hemophilia  coagulación 

Su riesgo de desarrollar trastornos hemorrágicos puede aumentar por la edad, el historial familiar y genético, otras afecciones médicas y medicinas, y el sexo.

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NHLBI

Trastornos hemorrágicos - Causas

hemophilia 

Sus genes u otras causas, como afecciones médicas o medicinas, pueden causar trastornos hemorrágicos. Algunas veces, es posible que se desconozca la causa. Cualquier problema que afecte la función o el número de factores de coagulación o plaquetas puede generar un trastorno hemorrágico.

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NHLBI

Anemia de células falciformes - Tipos

hemoglobina 

Las personas que tienen la anemia de células falciformes tienen hemoglobina anormal, llamada hemoglobina S o hemoglobina falciforme, en sus glóbulos rojos. La hemoglobina es una proteína en los glóbulos rojos que transporta el oxígeno por todo el cuerpo. Las personas que tienen la anemia de células falciformes heredan dos genes de hemoglobina anormales, uno de cada padre.

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NHLBI

Alpha-1 Antitrypsin Deficiency - Diagnosis

inflammation  liver  Protein  lungs 

AAT deficiency usually is diagnosed after you develop a lung or liver disease that is related to the condition. But knowing the symptoms and getting an early diagnosis is important to help prevent serious disease, especially with treatment and lifestyle changes.

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NHLB

Alpha-1 Antitrypsin Deficiency - Signs, Symptoms, and Complications

inflammation  liver  Protein  lungs 

The first lung-related symptoms of AAT deficiency may include shortness of breath, less ability to be physically active, and wheezing. Some people may not have any symptoms or complications. AAT deficiency can lead to lung and liver diseases.

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NHLBI

Alpha-1 Antitrypsin Deficiency - Causes

inflammation  liver  Protein  lungs 

Alpha-1 antitrypsin (AAT) deficiency happens when you do not make enough AAT protein. The AAT protein is made in your liver. This protein enters your blood and protects your organs, including the lungs, from damage. For example, your immune system is your body’s defense against bacteria and viruses but if it is overactive, it can damage your body while fighting diseases. The AAT protein prevents you from having too much inflammation in your lungs. Without enough AAT protein, your immune system may damage your lungs and lead to lung disease.

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NIH - Office of Research on Women's Health

Methods & Techniques for Integrating Sex into Research

One of the fundamental variables in preclinical biomedical research is sex: whether a cell, tissue, or animal is female or male. Biological sex is an important consideration for this research that underlies drug development, clinical trials, and prevention approaches.

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NIH - Office of Research on Women's Health

NIH Policy on Sex as a Biological Variable

NIH expects that sex as a biological variable will be factored into research designs, analyses, and reporting in vertebrate animal and human studies. Strong justification from the scientific literature, preliminary data, or other relevant considerations must be provided for applications proposing to study only one sex.

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NHLBI

Marfan Syndrome – Living With

MFS 

If you have been diagnosed with Marfan syndrome, it is important to follow your treatment plan, make healthy lifestyle changes, and get mental health support. Learn how to prevent or reduce complications in the future. If you are thinking about becoming pregnant, discuss the possible risks with your doctor.

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