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NIEHS

The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease

health  research  science  arthritis  diabetes  environment  north carolina  clinical  study  stress  patient  dexamethasone  metabolic disease  glucocorticoid receptor snps  volunteer  hormones  clinical study  recruitment  open study  Durham 

NIEHS researchers theorize that changes in the surface proteins of cells called receptors may predispose people to diseases, such as heart disease, arthritis, and diabetes.

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NIEHS

Lupus

health  research  science  environment  immune system  lupus  chronic disease  autoimmune diseases 

Lupus is a chronic disease that causes the immune system to attack the body’s own tissues and organs, resulting in inflammation of the skin, joints, blood, and kidneys.

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NIEHS

Mold

health  research  science  asthma  molds  environment  house  home  environmental agents  breathing  breath 

Molds are microscopic organisms that play an important role in the breakdown of plant and animal matter.

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NIEHS

Cookstoves and Indoor Air

health  research  science  cooking  global  environment  COPD  Global Health  cookstove smoke  chronic obstructive pulmonary disease  indoor air  global environmental health  geh  breathing  pollution  fire  breath  stove 

Three billion people, nearly half of the world's population, use inefficient stoves to cook their daily meals.

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NIEHS

RNA Isolation from Pico-scale samples (1 cell (10-25pg) - 10mg tissue) with the PicoPure

health  research  science  environment  laboratory  protocol  rna isolation  extraction of high quality rna  picopure  animal tissue  rat liver 

Protocol for Use with CapSure™ Macro LCM Caps; Protocol for Use with <10mg Frozen Tissue

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NIEHS

Vectorborne and Zoonotic Diseases

health  research  science  global  environment  malaria  rodent  dengue  mosquito  drought  tick  avian flu  Global Health  global environmental health  geh  health impacts of climate change  vectorborne and zoonotic diseases  Yellow Fever  Schistosomiasis  rat 

Vectorborne and zoonotic diseases (VBZD) are infectious diseases whose transmission involves animal hosts or vectors.

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NIEHS

Sample Collection Registry for Quality Control of Biological and Environmental Specimens and Assay Development and Testing

health  research  science  environment  north carolina  clinical  study  patient  sample collection registry for quality control of biological and environmental specimens  volunteer  clinical study  recruitment  open study  Durham  Raleigh  RTP 

Researchers are interested in developing a registry protocol to obtain biologic and environmental samples anonymously from adult volunteers for use in laboratory tests and studies.

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NIEHS

Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders

health  research  science  environment  maryland  immune  clinical  study  DC  patient  bethesda  families with twins  systemic rheumatic disorders  pathogenic studies  rheumatic  volunteer  clinical study  recruitment  open study  autoimune 

The goal of this study is to examine the genetic and environmental risk factors in the development of autoimmune diseases in twins and same-sex siblings, when one has an autoimmune disease and the other does not.

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NIEHS

Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage

health  research  science  environment  north carolina  clinical  study  patient  p53  dna damage  volunteer  clinical study  recruitment  open study  Durham  Raleigh  RTP  healthy volunteer 

The gene p53 suppresses cancer and inflammation in the body, and NIEHS investigators speculate that changes in p53 lead to changes in inflammation and the ability to repair DNA damage.

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NIEHS

Air Pollution

carbon monoxide  health  research  science  environment  air  environmental agents  ozone  outdoor air pollution  indoor air pollution  breathing  breath  particulate  haze  sulfur dioxide  nitrogen oxide 

Air pollution is a mixture of natural and man-made substances in the air we breathe. It is typically separated into two categories: outdoor air pollution and indoor air pollution.

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